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Indian J Pathol Microbiol ; 2008 Jul-Sep; 51(3): 315-22
Artigo em Inglês | IMSEAR | ID: sea-72871

RESUMO

We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.


Assuntos
Adulto , Idoso , Antígenos CD20/biossíntese , Leucossialina/biossíntese , Antígenos CD5/biossíntese , Antineoplásicos/uso terapêutico , Medula Óssea/patologia , Ciclina D1/biossíntese , Feminino , Trato Gastrointestinal/patologia , Hospitais , Humanos , Índia , Linfoma de Célula do Manto/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Análise de Sobrevida
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